224 Although, there is evidence to suggest that islet alpha-cells can secrete GLP-1 during healthy circumstances and that this secretion becomes elevated during diabetic/disease conditions, whether these cells secrete GLP-1 and the physiological relevance of this remains unclear
Even patients who dont lose weight on GLP-1s will often still see improvements in blood sugar if they have diabetes
While some weight regain can happen after discontinuing GLP-1 therapy, staying committed to these strategies can make a big difference in preserving your progress
Behavioral strategies proven effective for weight maintenance include consistent self-monitoring of weight (at least weekly), food logging, regular meal patterns, and cognitive behavioral techniques to address emotional eating and environmental triggers
Diabetes Care 45(1):134141 Koekkoek PS, Kappelle LJ, van den Berg E, Rutten GE, Biessels GJ (2015) Cognitive function in patients with diabetes mellitus: guidance for daily care
This does not mean single-agonist medications are ineffective