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STATINS AND ISOPRENYLATED PROTEINS By inhibiting L-mevalonic acid synthesis, statins also prevent the synthesis of other important isoprenoid intermediates of the cholesterol biosynthetic pathway, such as farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) (11) (Figure 2)

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These differences limit direct comparability with preclinical models, where intraperitoneal, subcutaneous, or non-thermally processed oral administration for cannabinoids is typically used

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