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592,593 Moreover, due to the decrease of 3-hydroxykynurenine (a cytotoxic metabolite of KMO), the mice that lack active kynurenine 3-monooxygenase (KMO) will not develop into AKI after I/R injury
coli , particularly Escherichia coli NC101 [33]
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Furthermore, TMAO levels have been reported to correlate with atherosclerotic plaque dimension and risk for cardiovascular events, such as myocardial infarction, stroke, and death over 3 years [67]
This mechanism increases nitric oxide production, which is essential for endothelial cell proliferation, vessel dilation, and new capillary formation
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