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doi: 10.1007/s13311-011-0047-z

Incorporating these strategies during lead optimization can help reduce immunogenicity-related risks and minimize the possibility of late-stage clinical attrition

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Furthermore, interactions between SFN and Glutathione S-Transferase P1 (GSTP1) gene variants have been observed, where SFN can modulate the expression levels of different GSTP1 haplotypes (54)