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The cause is mechanical: semaglutide slows gastric emptying and small intestinal transit, which means stool moves through the colon more slowly and water gets reabsorbed more thoroughly
Other peptides used clinically are prepared by an FDA registered cGMP sterile laboratory complying with all state and federal laws
Because compounded drugs are not FDA-approved, an unnamed pharmacy removes a key way to verify sourcing
In the pancreas, they enhance glucose-dependent insulin secretion whilst suppressing inappropriate glucagon release, thereby improving glycaemic control without causing hypoglycaemia
This is especially relevant for GLP-1 users who report feeling like the stool is right there but will not come out, or who experience excessive straining despite having soft stool