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Kerksick, C., & Willoughby, D

MBBS, MRCGP, DFSRH, DRCOG Dr Meenakshi Raina is an experienced GP with more than 20 years of clinical experience in the NHS

While prior reviews have covered curcumins chemical composition and biological activities, this work goes further by integrating the latest advancements in several key areas

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In a crossover study by Vrieling et al., lycopene was observed to increase the concentrations of circulating insulin-like growth factor binding proteins (IGFBP)-1 and 2, thereby reducing the binding of IGF-I to its receptor, which may indirectly result in decreased bioavailability of IGF-I, potentially playing a preventive role in the development of colorectal cancer (Vrieling et al., 2007) (Figure 3)

doi: 10.3390/jpm11080735 29 HenningS