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Benzing WC, Mufson EJ, Jennes L, Armstrong DM (1990) Reduction of neurotensin immunoreactivity in the amygdala in Alzheimers disease

In line with this, hepatocyte-specific knockout of -arrestin 2 (arr2) leads to substantial increases in GcgR signaling with concomitant decreases in GcgR internalization, resulting in approximately 2x greater cAMP and glucose production in glucagon-stimulated primary hepatocytes [198]

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Salem ME, Andre T, El-Refai SM, Kopetz S , Tabernero J, Sinicrope FA, Tie J, George TJ, VanCutsem E, Mauer E, Lonardi S, Overman MJ, Foureau D

The effect it has on the body is dependent on metabolic state, with the greatest beneficial effects being seen in fasted subjects