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These events are rare and more common in patients with pre-existing risk factors: prior history of pancreatitis, high triglycerides, heavy alcohol use, or genetic predisposition

This excessive production of radical oxidants can occur in pathological states where mitochondrial function is impaired [3], as is common in numerous metabolic diseases [46], as well as infection

For example, TNF- and IL-6 reduced the production of NO by inhibiting the phosphorylation of eNOS (79)

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For example, while we concluded that Uretero1 TM met the criterion for substantial clinical improvement, we note that CMS agreed that the evidence demonstrated improved outcomes for the disposable device (singular), i.e., Uretero1 TM (87 FR 71932)

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