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Among all these cerebellar mutant models, the Lurcher mouse, discovered in the Medical Research Council Radiobiological Research Unit at Harwell, England, in 1954 [15] is still of great interest

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Therefore, this review tries to explain the different possible mechanisms behind the depletion of dopamine in PD patients such as alpha-synuclein abnormalities, mitochondrial dysfunction, and 3,4-dihydroxyphenylacetaldehyde (DOPAL) toxicity, along with the current therapies we have and the ones that are in development

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