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Protection of the BBB, the inhibition of the elements of the brain microvascular damage such as impairment of tight junctions, increased vesicular transcytosis, production of various cytokines, chemokines and reactive oxygen species offers novel therapeutic targets [11]

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Any unexplained, persistent tachycardia (heart rate increase of 1020 beats per minute has been observed in clinical trials) should be evaluated

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UK practice involves risk-based assessment considering medication type, dosage, gastrointestinal symptoms, procedure complexity, and individual patient factors rather than universal cessation