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store reconstituted material at 4C and use within ~30 days

Higher daily doses of 50 to 250 mcg are needed in cases of maternal deficiency

B12 supplements or B12 shots

By inhibiting NNMT, 5-Amino-1MQ in principle preserves more nicotinamide for NAD+ salvage

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Mechanistically, intra-articular AOD-9604 may stimulate synovial fibroblast proliferation or reduce inflammatory cytokine production in the synovial microenvironment, though direct effects on cartilage are unclear