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Many of the letters cite claims implying that compounded GLP-1 drugs have been FDA approved, evaluated for safety and effectiveness, or are the same as FDA-approved reference products

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For assessment of glucose-induced insulin secretion, glucose was given orally at a dose of 4 g kg 1 in 6 h fasted mice, followed by blood sampling at timepoints 0, 2, 5, 15 and 30 min after glucose administration

Understanding this history is key to recognizing how GLP-1s have evolved, moving from a niche diabetes treatment to a cornerstone of obesity and chronic disease management today

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