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First, as described above, GLP-1R expression in pancreatic -cells is downregulated under diabetic conditions

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The metabolism process takes place in the intestines, liver and kidneys and the accumulation tends to happen in those organs

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Abbreviations AChE: Acetylcholinesterase Bti : Bacillus thuringiensis israelensis CHC: Cuticular hydrocarbon CPR: NADPH-cytochrome P450 reductase CYP: Cytochrome P450 DDT: Dichlorodiphenyltrichlorethane F: Phenylalanine GABA: -Aminobutyric acid GST: Glutathione S -transferases H: Histidine kdr : Knockdown resistance L: Leucine LLINs: Long-lasting insecticide nets PBA1c: 3-Phenoxybenzyl alcohol PBA1d: 3-Phenoxybenzaldehyde PBAcid: 3-Phenoxybenzoic acid RDL : Resistance to dieldrin gene S: Serine Vssc: Voltage-sensitive sodium channel References World Health Organization