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growth, which continues to be resilient, and some of it mirrors other cycles

doi: 10.1359/jbmr.070305 4

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Non-genetic predictors of BMI loss To analyse the dependence of achieved BMI loss on non-genetic factors such as drug type, dosage and time on treatment, we fit the following model: where drugType is an indicator variable that equals 1 for individuals using semaglutide and 0 for tirzepatide, dose represents the dose in milligrams, days treat represents the total days on the relevant drug and : represents an interaction term between two or more variables

Linker chemistry plays a critical role, where disulfide (SS) or diselenide (SeSe) bonds connect the drug to the carrier, enabling selective cleavage under reducing conditions