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Disadvantages are poor stability, high production cost, and high production difficulty

N Engl J Med 375(4):311322 Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jdar E, Leiter LA, SUSTAIN-6 Investigators et al (2016b) Semaglutide and cardiovascular outcomes in patients with type 2 diabetes

Storage Requirements Storage conditions differ dramatically between unreconstituted and reconstituted peptide

Phase 1 analog data CB4211, a synthetic MOTS-c analog, completed a Phase 1a/1b trial reported as safe and well tolerated

DOI: 10.1016/j.ccc.2021.03.010

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