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This is still enormously useful because the shape of the curve, the peaks, troughs, and accumulation pattern, reflects real pharmacokinetic behavior

However, changes in stool colour can occur for several reasons when taking medications that affect digestion

3.2.4 Ferroptosis and amyotrophic lateral sclerosis ALS is a lethal NDD characterized by progressive degeneration of upper and lower motor neurons in the cerebral cortex, brainstem, and spinal cord, leading to skeletal muscle atrophy, weakness, weight loss, dysarthria, dysphagia, paralysis, and ultimately death from respiratory failure (Urano et al., 2025)

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Nature 439 , 484489 (2006)

doi: 10.1080/10715762.2023.2212121 115 GaschlerMMStockwellBR