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A lower Firmicutes/Bacteroidetes ratio (142), reduced counts of Lactobacillaceae (143), and altered abundance of several genera have been reported (144) including Eggerthella , Klebsiella , Flavonifractor , Lachnospiraceae (145, 146), Prevotella , Eubacterium, and Rhodococcus were significantly enriched, whereas Pseudobutyrivibrio and Dialister were decreased in SLE patients (147)

Phase III refers to work that derives from, extends, or completes an effort made under prior SBIR funding agreements, but is funded by sources other than the SBIR Program

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doi: 10.1016/j.celrep.2019.05.105 494 WuSJiangZYSunYFYuBChenJDaiCQet al

PD-1 is predominantly expressed on T cells, and upon binding to PD-L1, T-cell receptor (TCR)-mediated activation is inhibited (80)

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