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Furberg, A

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Throughout this article, note that Retatrutide is not yet FDA-approvedit remains investigational, though phase III results show impressive outcomes

Early studies suggest that GLP-1s may enhance dopamine signalling and reduce neuroinflammation, which could improve motivation and resilience, as stronger dopamine signalling means less fatigue and better motivation, and reduced neuroinflammation supports mental clarity

Both peptides cause transient nausea in 4060% of users through central MC4R activation, but PT-141's nausea resolves within 46 hours per dose while Melanotan-2's nausea typically diminishes after the first week of repeated use

Additionally, the inflammation-induced clot formationalso referred to as immunothrombosis further exacerbates VTE risk in people living with obesity