The expression of the gene encoding heparanase is regulated epigenetically and by tumor suppressor p53, but can also be induced by early growth response stimulation of transcription factor-1, reactive oxygen species, and inflammatory cytokines (64)
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Reich K, Gooderham M, Bewley A, Green L, Soung J, Petric R, Marcsisin J, Cirulli J, Chen R, Piguet V (2018) Safety and efficacy of apremilast through 104 weeks in patients with moderate to severe psoriasis who continued on apremilast or switched from etanercept treatment: findings from the LIBERATE study
Recent findings indicate that muscle-specific genes (i.e., myosin heavy chain) and their products must be targeted to initiate muscle wasting [29]
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