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For both patients and health plans, the drugs alone are an unsustainable model in terms of financial toxicity, whether we are talking about a patient-as-payors wallet for $12K+ a year, or to the health plans bottom-line and per-member/per-month medical trend spending

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Twice as many participants discontinued orforglipron than semaglutide due to adverse events

Additionally, internalized receptors and GPCR:-arrestin complexes can continue to signal from the endosome, with this process potentially engaging alternative signalling cascades (Willard et al., 2020)