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A substudy published in Nature Medicine enrolled 98 participants with MASLD for 48 weeks (Nature Medicine, 2024): At 12 mg, 93% of participants with fatty liver achieved normal liver fat levels

37 Progress gradually, focusing on one change at a time

The Phase 2 trial data confirms this: the 1mg dose group achieved only 8.7% weight loss at 48 weeks, indicating that low doses produce modest effects that accumulate slowly