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10.1016/j.molmet.2015.03.005 14

Many treatments approved for T2DM treatment such as sulphonylureas and thiazolidinediones (TZDs) improve glucose metabolism but have the unwanted side effect of causing weight gain (Thule and Umpierrez, 2014) and (Kahn et al., 2006

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Rather than targeting a single pathway, this peptide combination activates multiple interconnected signaling networks across incretin and amylin receptor systems that collectively enhance metabolic responses beyond what individual components might achieve alone

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Although neutralization in vitro is probably the best predictor of in vivo efficacy, there are numerous examples of deviation from a uniform relationship between neutralization and protection and/or therapy