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This is one mechanistic reason IV and parenteral administration have shown some tissue-level effects in animal studies

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Van Den Heuvel AP, Jing J, Wooster RF, Bachman KE (2012) Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth

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Chen L, Shi X-J, Liu H, Mao X, Gui L-N, Wang H, et al

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