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Despite these promising findings, translation of GHSR antagonists and inverse agonists from preclinical models to clinical trials remains challenging

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doi: 10.1056/NEJM199502233320801

The price difference reflects formulation complexity: oral semaglutide requires specialized sublingual delivery technology to protect the hormone from stomach acid, increasing manufacturing costs

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Discovery and evaluation of DA-302168S as an efficacious oral small-molecule glucagon-like peptide-1 receptor agonist