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It was shown that ATLL cells as well as HTLV-1-infected cells secreted not only IL-6 but other HGF inducers such as IL-1 and TNF-, through which the production of HGF in stromal cells could be upregulated [5456]

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The breadth of the gene expression effects has been one of the more striking findings in the GHK-Cu literature, with some studies reporting effects on more than 4,000 genes at certain doses and exposure times

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