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In addition to counteracting BBB hyperpermeability by inhibiting the production of pro-inflammatory cytokines and ROS, VD has been shown to exert direct effects on ECs by up-regulating the expression of TJ proteins such as zonula occluden (ZO)-1 and claudin-5 while simultaneously down-regulating the levels of cell adhesion molecules such as ICAM-1 and VCAM-1, which collectively promotes the stabilization of the BBB [76]

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Gene expression of a truncated and the full-length growth hormone (GH) receptor in subcutaneous fat and skeletal muscle in GH-deficient adults: impact of GH treatment

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