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Clinical pharmacokinetic studies demonstrate that the lag time between oral ingestion of L-theanine and its absorption into the bloodstream is incredibly short, often measuring just 10 to 20 minutes

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Genome-wide methylation comparisons between 65 DS and 59 NS healthcare workers revealed 21 loci in circadian genes, including PER3 and CSNK1E, to be significantly hypomethylated among NSW, highlighting potential epigenetic mechanisms underlying shift work-associated disease risk 214

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doi: 10.1016/S0140-6736(18)32744-2