Long-acting analogs benefit from their extended half-lives in a different way
Vitamin B12 deficiency is a common concern for people with diets low in B12
However, we cant say for sure how much of an improvement there could actually be without more research (particularly human research)
Furthermore, GST fusion proteins are susceptible to TG2-mediated aggregation, independent of the specific fused protein that is used
The publicly available datasets used can be found under PDB accessions 3HU1, 3HU2, 3HU3, 4KO8, 5C1A, 5FTK, 5FTL, 5FTM, 5FTN, 7JY5, 7LMY, 7LMZ, 7LN0, 7LN1, 7LN2, 7LN3, 7LN4, 7LN5, 7RLA, 7RLC, 7RLF, 7RLH, 7RLJ, 7RL7, 7VCS, 7VCT, 7VCU, 7VCV and 7VCX
It then plays a big role in signalling tissue remodelling, removing damaged/scarred tissue and generating new, healthy tissue