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K-means clustering of amplicon sequence variant data confirmed that 5-Amino-1MQ treatment generated a distinct cecal microbiome profile from all other treatment groups including diet-switched vehicle controls indicating that NNMT inhibition produces microbiome changes that are separable from those produced by dietary composition alone

Recall, estrogen levels begin to decline around 30 years of age in women [9, 10], so the clinical trials selected for presentation include participants who were aged 30 to over 65 years

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