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In addition, due to the ability of metformin to cross the placenta, continued use of metformin for GDM during pregnancy still raises concerns about its safety and potential adverse effects on the fetus

Reconstitution mixes that powder with bacteriostatic water (BAC water) to create an injectable solution

The size of any benefit varies between studies

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Should this prospect be dismissed, an exhaustive exploration of other potential culprits is imperative, including systemic causes (both hepatic and extrahepatic), neurological disorders, and psychogenic triggers (20)

1 2 3 Yan J, Meng X, Wancket LM, Lintner K, Nelin LD, Chen B, Francis KP, Smith CV, Rogers LK, Liu Y (marzo de 2012)