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Human IgE-producing myeloma U266 cells demonstrated significant and dose-dependent reductions in IgE production with XPP treatment (IC 50 = 9 g/mL) [64]

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The disease is very severe if the female has defective copies of both X genes

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NRF2 activation disrupts the Smad signaling pathway downstream of TGF-, preventing the formation of Smad complexes and their translocation to the nucleus [125]

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