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The study confirmed FOXO4-DRI was effective across senescent cells generated by different methods (irradiation, doxorubicin, and replication stress), and documented that pre-treatment with FOXO4-DRI attenuated the dedifferentiation of chondrocytes during in vitro expansion establishing it as a valuable tool for research into senescent cell biology in cartilage and musculoskeletal models

But these adaptations also unearthed deeper systematic issues

153 Therefore, GLP-1RA may be effective in MetALD and may provide benefits for the metabolic components of ALD