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Clinical implications and interventions An increasing body of evidence indicates that Vitamin D deficiency is highly prevalent among the elderly, particularly in individuals with insufficient sunlight exposure, impaired cutaneous synthesis, or chronic inflammatory skin conditions [248,249,250]

More serious risks include the potential for thyroid tumors, pancreatitis, or kidney issues, although these are rare

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While this approach can support sustainable weight management with fewer side effects, it remains off-label and lacks robust clinical data

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Cost and Scale: Chemical synthesis is suited for producing small to medium quantities efficiently and with high purity, driving some preference during manufacturing for clinical trials and for therapies of smaller indications