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In a large cohort study from the United States involving more than 18,000 overweight or obese individuals, Rodriguez et al reported that the average weight loss after one year was 8.3% with semaglutide and 15.3% with tirzepatide

Diarrhoea initiates during the first four weeks of treatment, after which the incidence notably decreases [15,49]

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This makes sense when you consider that you are actively changing the bacterial composition of your gut