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GLP-1 medications can occasionally cause dehydration if a patient experiences vomiting or diarrhea

In contrast, anorexigenic intestinal peptides as peptide YY (PYY), pancreatic polypeptide (PP), GLP-1, oxyntomodulin and cholecystokinin are low during the fasting period, and their level increases after a meal, and some of them are released proportionally to the amount of calories ingested (Reviewed in [127])

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It is available through licensed medical providers for investigational and compounded use