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Karl Nadolsky, an obesity-medicine specialist and AACE member, has stated: "Restricting access to GLP-1 receptor agonists through excessive step therapy contradicts the evidence base and delays treatment for a disease with cumulative cardiometabolic harm." The disconnect between this evidence and Kaiser's access barriers represents one of the more visible friction points in obesity pharmacotherapy coverage

Inhibition of GLS expression results in reduced immunoglobulin (Ig) G and IgM antibody production, and glutaminase blockade decreased downstream mTOR activation and attenuated IL-10 secretion [121, 141, 142]