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These computational findings are consistent with experimental and preliminary clinical evidence, including observational studies and randomized clinical trials, suggesting that metformin may reduce the risk of AD and comorbid AD in individuals with DM2 while also enhancing cognitive performance 52,53,54,55,56,57

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(169) showed diabetic animal models administered berberine activates the Nrf2 pathway and decreases OxS

doi: 10.1038/nature08833

A healthy body produces enough alpha-lipoic acid endogenously to supply its requirements as an enzyme cofactor