IGF-1 plays a central role in tumor development by stimulating proliferation and inhibiting apoptosis in cancer cells. Pollak, Nature Reviews Cancer Acromegaly-Like Symptoms (Rare) In extremely high or prolonged dosesespecially when stacked with HGHIGF-1 may contribute to: Bone thickening (jaw, forehead, hands) Enlarged soft tissue Headaches or carpal tunnel symptoms These side effects mimic acromegaly , a condition caused by excessive GH/IGF-1 signaling
33 The coronal sections used for punches of the dDG were taken from 2.3 to 4.3 mm from bregma
however, intranasal delivery can also reach the CNS via olfactory or trigeminal pathways, bypassing the BBB (Hanson and Frey 2008)
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DEN, @ PHI, @ WAS, @ MIL Last Week:27 Record: 16-43 OffRtg: 109.3 (29) DefRtg: 120.1 (28) NetRtg: -10.8 (30) Pace: 102.2 (6) The Wizards have lost four straight games, but they remain in 13th place in the Eastern Conference, because the two teams behind them the Nets and Pacers have longer active streaks
doi:10.1016/j.phrs.2007.01.009
