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Osaka T, Tsukamoto A, Koyama Y, Inoue S

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[14] successfully isolated exendin-4 from the venom of the Gila monster (Heloderma suspectum), a lizard known for its infrequent but large meals weighing up to as much as one third of its body masssuggesting the presence of adaptive metabolic mechanisms in the species [14,15]

However, only a small amount of metformin was transported through the outer basement membrane of the small intestinal epithelial cells into the bloodstream, resulting in metformin accumulation in these cells (Proctor et al., 2008)

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Front Pharmacol (2022) 13:1016639