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There is also evidence that peripheral inflammation driven by gut dysbiosis can reduce expression of key protein degradation systems in the brain (such as ubiquitinproteasome pathway and autophagy genes), thereby accelerating the accumulation of toxic proteins [101]

Research interest focuses on its interaction with multiple hormonal systems simultaneously, supporting advanced experimental models designed to explore integrated metabolic regulation

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In investigations regarding hepatic ischemiareperfusion injury, Eritoran, a crucial TLR4 antagonist, mitigates liver inflammation and cellular impairment through the blockade of the HMGB1TLR4 axis [367]