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The molecule is built on a glucagon-family backbone with a long fatty acid side chain designed to extend the peptide's half-life.nnWhat sets retatrutide apart is that a single molecule activates three different receptors at once: GLP-1, GIP, and glucagon

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Retatrutide data on this point is still being collected through the TRIUMPH maintenance arms

Retatrutide has a half-life of approximately 6 days, according to the Phase 2 trial published in the New England Journal of Medicine (Jastreboff et al., 2023)

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Sleep problems are not currently recognised as one of the main retatrutide side effects