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Overexpression of human GH in transgenic mice has been reported to increase the percentage of type I fibres (Dudley and Portanova, 1987) and in GH receptor knockout mice there are fewer type I fibres and more type II fibres relative to the wild-type animals (Sotiropoulos et al ., 2006)
Instrumental variables were identified as single nucleotide polymorphisms linked to the exposure, and analyses utilized inverse variance weighting as the primary method, followed by sensitivity assessments
In turn, the levels of IGF-1 have been shown to be associated with an increased risk of cancer (204, 205)