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This is often the main reason people think about switching

Skipping this step increases risks of adverse events and treatment failure

According to meta-analyses of cohort studies, each 1 mg/dL (59.48 mol/L) increase in serum levels of UA increases the risk of developing T2DM by about 617 % [19,20,21]

Concerns about lean mass loss and metabolism Clinical data shows semaglutide can reduce lean body mass, with losses ranging from nearly 0% to 40% of total weight reduction

This is where most people notice the clearest difference compared to week one

They can help determine whether the medication is the cause and what steps to take next