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[Updated 2023 Jan 13]

Clinical trials show that when people lose weight on GLP1 drugs such as semaglutide and tirzepatide, they lose both fat and lean mass

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"Patients may also notice their genital region more with weight loss if it was previously hidden by significant fat in the pubic and lower abdominal region." Not only can volume loss change the appearance of these structures, but loose skin can also cause discomfort, chaffing and irritation

J Clin Invest 2015;125:782786.ArticlePubMedPMC 84