Secondary, safety and negative control endpoints For individual components of the primary endpoint, semaglutide versus sitagliptin reduced myocardial infarction (HR 0.81, 95% CI 0.70 to 0.92) and stroke (HR 0.84, 95% CI 0.71 to 0.99) in the expanded populations at low, moderate and high cardiovascular risk
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If 8mg produces good weight loss results with acceptable tolerability, remaining at that dose is a clinically reasonable outcome
Affiliation: 1 College of Medicine, University of Florida, Gainesville, FL 32608, USA Email: [email protected] ORCID: Affiliation: 1 College of Medicine, University of Florida, Gainesville, FL 32608, USA ORCID: Affiliation: 1 College of Medicine, University of Florida, Gainesville, FL 32608, USA ORCID: Affiliation: 1 College of Medicine, University of Florida, Gainesville, FL 32608, USA ORCID: Affiliation: 1 College of Medicine, University of Florida, Gainesville, FL 32608, USA ORCID: Affiliation: 1 College of Medicine, University of Florida, Gainesville, FL 32608, USA ORCID: Affiliation: 1 College of Medicine, University of Florida, Gainesville, FL 32608, USA ORCID: Affiliation: 2 Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA ORCID: Explor Drug Sci
However, early studies have begun to show patterns
Sometimes the solution is simpler