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Ultimately, integrating robust biomarkers, multi-omics, and AI is the most promising path to tailor therapies to individual redox profiles, finally fulfilling the promise of antioxidant strategies and improving MIRI outcomes
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Salmonella typhimurium induces the destruction of M cells following uptake thereby attenuating gut barrier integrity (Fine et al
Elevated levels of 1-antitrypsin can also inhibit neutrophil elastasemediated degradation of IL-1 and IL-6, leading to recurrent inflammation ( 9 Potential therapeutic strategies for tophi As a defining feature of advanced gout, tophus formation reflects a complex pathophysiological process driven by the combined influences of MSU crystal deposition, chronic inflammation, and fibrotic tissue remodeling