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In 2017, Cohen proposed a novel (topically administered) double therapy for melasma that combine an anti-estrogen and a vascular endothelial growth factor inhibitor

Reduced GSH and oxidized GSSG In the body, glutathione mainly exists in two interconvertible forms: reduced glutathione (GSH) and oxidized glutathione (GSSG), and the balance between these forms reflects cellular redox status

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Lizcano F, Sanabria D, Aviles E