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2009 RCT documented improvements in mottled hyperpigmentation alongside fine-wrinkle reduction in photoaged skin 10

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(2015) [11] were excluded because they did not report on free testosterone levels

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A randomized (159), double-blind, placebo-controlled trial involving 46 adult SLE patients (23 in the synbiotic group, 23 in the placebo group) showed that 60 days of synbiotic supplementation significantly increased butyrate metabolism, reduced the pro-inflammatory cytokine IL-6, and inhibited the elevation of hs-CRP

Unhealthy Gut : A disrupted microbiome can influence immune function