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van Bloemendaal L, Ten Kulve JS, la Fleur SE, Ijzerman RG, Diamant M
Here, we have used glucagon-like peptide-1 (GLP-1) as a model peptide therapeutic for treating obesity-linked type 2 diabetes, a common chronic disease
In contrast this study indicates that H 2 S acts downstream of the cAMP generation induced by TGR5 activation, most likely by inhibiting PI hydrolysis and the subsequent increase in intracellular calcium needed for vesicle release from the enteroendocrine cells
Growth/differentiation factor-15 (GDF-15) Another potential therapeutic pathway for obesity pharmacotherapies is through the stress-induced cytokine GDF-15, which is expressed in multiple cell types including cardiomyocytes, adipocytes and macrophages [98]