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Rotating between sites helps prevent local tissue irritation

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However, therapeutic effects begin to diminish sooner, with blood glucose levels typically rising within 12 weeks of discontinuation

Moreover, the American Heart Association (AHA) 23 recommends that neurologists use GLP-1RAs as part of their stroke prevention strategies for patients with type 2 diabetes at high risk of stroke

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Primary effects: All GLP-1 effects plus enhanced insulin secretion, possible direct effects on fat metabolism, potentially reduced nausea through GIP-mediated pathways